Zinc Finger Proteins in Neuro-Related Diseases Progression

Siyuan Bu; Yihan Lv; Yusheng Liu; Sen Qiao; Hongmei Wang

doi:10.3389/fnins.2021.760567

Zinc Finger Proteins in Neuro-Related Diseases Progression

Front Neurosci. 2021 Nov 18:15:760567. doi: 10.3389/fnins.2021.760567. eCollection 2021.

Authors

Siyuan Bu¹, Yihan Lv¹, Yusheng Liu¹, Sen Qiao², Hongmei Wang¹

Affiliations

¹ Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China.
² Department of Pharmacology, Center for Molecular Signaling (PZMS), School of Medicine, Saarland University, Homburg, Germany.

Abstract

Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases. The purpose of this review is to summarize the types and roles of ZNF in neuropsychiatric disorders. We will describe the structure and classification of ZNF, then focus on the pathophysiological role of ZNF in neuro-related diseases and summarize the mechanism of action of ZNF in neuro-related diseases.

Keywords: Alzheimer’s disease; autism spectrum disorder; epilepsy; ischemic stroke; neuro-related diseases; schizophrenia; zinc finger proteins.

Publication types

Review