The bone at the intersection of kidney and heart disease

Isaac Campos; Christian Faul

doi:10.1016/j.tips.2021.11.014

The bone at the intersection of kidney and heart disease

Trends Pharmacol Sci. 2022 Feb;43(2):84-86. doi: 10.1016/j.tips.2021.11.014. Epub 2021 Dec 2.

Authors

Isaac Campos¹, Christian Faul²

Affiliations

¹ Division of Nephrology and Hypertension and Section of Mineral Metabolism, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
² Division of Nephrology and Hypertension and Section of Mineral Metabolism, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: cfaul@uabmc.edu.

PMID: 34865884
DOI: 10.1016/j.tips.2021.11.014

Abstract

Systemic inflammation and elevations in the hormone fibroblast growth factor 23 (FGF23) contribute to cardiac injury and death in patients with kidney disease. A new mechanistic study by Courbon et al. suggests that the bone connects the damaged kidney with the damaged heart by serving as the target for a kidney-derived proinflammatory factor and responding with FGF23 secretion.

Keywords: chronic kidney disease; fibroblast growth factor 23; inflammation; left ventricular hypertrophy; lipocalin 2.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Fibroblast Growth Factors / metabolism
Heart Diseases*
Humans
Hypertrophy, Left Ventricular / metabolism
Kidney / metabolism
Renal Insufficiency, Chronic* / metabolism

Substances

Fibroblast Growth Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding