Effect of Bayesian penalty likelihood algorithm on 18F-FDG PET/CT image of lymphoma

Abstract

Objective: Recently, a new Bayesian penalty likelihood (BPL) reconstruction algorithm has been applied in PET, which is expected to provide better image resolution than the widely used ordered subset expectation maximization (OSEM). The purpose of this study is to compare the differences between these two algorithms in terms of image quality and effects on clinical diagnostics and quantification of lymphoma.

Methods: A total of 246 FDG-positive lesions in 70 patients with lymphoma were retrospectively analyzed by using BPL and OSEM + time-of-flight + point spread function algorithms. Visual analysis was used to evaluate the effects of different reconstruction algorithms on clinical image quality and diagnostic certainty. Quantitative analysis was used to compare the differences between pathology and lesion size.

Results: There were significant differences in lesion-related SUVmax, total-lesion-glycolysis (TLG), and signal-to-background ratio (SBR) (P < 0.01). The variation Δ SUVmax% and Δ SBR% caused by the two reconstruction algorithms were negatively correlated with tumor diameter, while Δ MTV% and Δ TLG% were positively correlated with tumor diameter. In the grouped analysis based on pathology, there were significant differences in lesion SUVmax, lesion SUVmean, and SBR. In non-Hodgkin's lymphoma (diffuse large B cells and follicular lymphoma), diversities were significantly found in SUVmax, SUVmean, SBR, and TLG of the lesions (P < 0.05). According to the grouped analysis based on lesion size, for lesions smaller than 1 cm and 2 cm, there was a significant difference in SUVmean, SUVmax, SBR, and MTV, but not in lesions larger than or equal to 2 cm (P > 0.05), and the liver background SUVmean (P > 0.05) remained unchanged.

Conclusion: BPL reconstruction algorithm could effectively improve clinical image quality and diagnostic certainty. In quantitative analysis, there were no significant differences among different pathological groups, but there were significant diversities in lesion sizes. Especially for small lesions, lesion SUVmax increased and SBR was significantly improved, which may better assist in the diagnosis of small lesions of lymphoma.