Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning

Bo Li; Ya-Qiu Li; Dongdong Zhao; Jie Yang; Yan-He Ma; Chang-Hao Bi; Xue-Li Zhang

doi:10.1016/j.jgg.2021.11.007

Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning

J Genet Genomics. 2022 Mar;49(3):254-257. doi: 10.1016/j.jgg.2021.11.007. Epub 2021 Dec 2.

Authors

Bo Li¹, Ya-Qiu Li², Dongdong Zhao², Jie Yang³, Yan-He Ma², Chang-Hao Bi⁴, Xue-Li Zhang⁵

Affiliations

¹ Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
² Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
³ Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300308, China.
⁴ Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China. Electronic address: bi_ch@tib.cas.cn.
⁵ Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China. Electronic address: zhang_xl@tib.cas.cn.

PMID: 34863920
DOI: 10.1016/j.jgg.2021.11.007

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Gene Editing*
Gene Library
Machine Learning*