Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock: a modelling study

Abstract

Background: In non-traumatic respiratory failure, pre-hospital application of CPAP reduces the need for intubation. Primary blast lung injury (PBLI) accompanied by haemorrhagic shock is common after mass casualty incidents. We hypothesised that pre-hospital CPAP is also beneficial after PBLI accompanied by haemorrhagic shock.

Methods: We performed a computer-based simulation of the cardiopulmonary response to PBLI followed by haemorrhage, calibrated from published controlled porcine experiments exploring blast injury and haemorrhagic shock. The effect of different CPAP levels was simulated in three in silico patients who had sustained mild, moderate, or severe PBLI (10%, 25%, 50% contusion of the total lung) plus haemorrhagic shock. The primary outcome was arterial partial pressure of oxygen (Pao₂) at the end of each simulation.

Results: In mild blast lung injury, 5 cm H₂O ambient-air CPAP increased Pao₂ from 10.6 to 12.6 kPa. Higher CPAP did not further improve Pao₂. In moderate blast lung injury, 10 cm H₂O CPAP produced a larger increase in Pao₂ (from 8.5 to 11.1 kPa), but 15 cm H₂O CPAP produced no further benefit. In severe blast lung injury, 5 cm H₂O CPAP inceased Pao₂ from 4.06 to 8.39 kPa. Further increasing CPAP to 10-15 cm H₂O reduced Pao₂ (7.99 and 7.90 kPa, respectively) as a result of haemodynamic impairment resulting from increased intrathoracic pressures.

Conclusions: Our modelling study suggests that ambient air 5 cm H₂O CPAP may benefit casualties suffering from blast lung injury, even with severe haemorrhagic shock. However, higher CPAP levels beyond 10 cm H₂O after severe lung injury reduced oxygen delivery as a result of haemodynamic impairment.

Keywords: computer simulation; continuous positive airway pressure; hypovolaemic shock; mathematical modelling; primary blast lung injury.