Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Yingkuan Shao; Kailun Xu; Xi Zheng; Biting Zhou; Xiuli Zhang; Lin Wang; Yaoting Sun; Dan Li; Ting Chen; Jian Wang; Shaojun Yu; Lifeng Sun; Xiaoming Xu; Shaozhi Dai; Huanhuan Gao; Guan Ruan; Wei Liu; Xue Cai; Tiansheng Zhu; Lina Qi; Jiani Chen; Wangxiong Hu; Xingyue Weng; Yi Zhu; Xueping Xiang; Zhiyuan Hu; Jinfan Li; Lirong Chen; Jimin Shao; Shu Zheng; Tiannan Guo

doi:10.1002/cac2.12240

Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Cancer Commun (Lond). 2022 Feb;42(2):164-169. doi: 10.1002/cac2.12240. Epub 2021 Dec 4.

Authors

Yingkuan Shao^{1

2

3}, Kailun Xu^{1

2

3}, Xi Zheng^{1

2

3}, Biting Zhou¹, Xiuli Zhang⁴, Lin Wang⁵, Yaoting Sun^{2

3}, Dan Li¹, Ting Chen¹, Jian Wang⁶, Shaojun Yu⁶, Lifeng Sun⁶, Xiaoming Xu⁷, Shaozhi Dai^{2

3}, Huanhuan Gao^{2

3}, Guan Ruan^{2

3}, Wei Liu^{2

3}, Xue Cai^{2

3}, Tiansheng Zhu^{2

3}, Lina Qi¹, Jiani Chen¹, Wangxiong Hu¹, Xingyue Weng¹, Yi Zhu^{2

3}, Xueping Xiang⁷, Zhiyuan Hu^{4

8

9}, Jinfan Li⁷, Lirong Chen⁷, Jimin Shao^{1

10}, Shu Zheng¹, Tiannan Guo^{2

3}

Affiliations

¹ Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, Department of Breast Surgery and Oncology, Second Affiliated Hospital, School of Medicine, Cancer Institute, Zhejiang University, Hangzhou, Zhejiang, 310009, P. R. China.
² Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang, 310024, P. R. China.
³ Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang, 310024, P. R. China.
⁴ CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
⁵ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.
⁶ Department of Colorectal Surgery, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, P. R. China.
⁷ Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, P. R. China.
⁸ School of Nanoscience and Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
⁹ Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350108, P. R. China.
¹⁰ Department of Pathology and Pathophysiology, Key Laboratory of Disease Proteomics of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, P. R. China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Movement
Colorectal Neoplasms* / drug therapy
Colorectal Neoplasms* / genetics
Humans
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
Proteomics*

Substances

PLOD2 protein, human
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase