Cytokine storm in tuberculosis and IL-6 involvement

Funmilayo Grâce Boni; Insaf Hamdi; Liadrine Moukendza Koundi; Kanchan Shrestha; Jianping Xie

doi:10.1016/j.meegid.2021.105166

Cytokine storm in tuberculosis and IL-6 involvement

Infect Genet Evol. 2022 Jan:97:105166. doi: 10.1016/j.meegid.2021.105166. Epub 2021 Nov 30.

Authors

Funmilayo Grâce Boni¹, Insaf Hamdi¹, Liadrine Moukendza Koundi¹, Kanchan Shrestha¹, Jianping Xie²

Affiliations

¹ Institute of Modern Biopharmaceuticals State Key Laboratory, Breeding Base Eco-Environment and Bio-Ressource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400700, China.
² Institute of Modern Biopharmaceuticals State Key Laboratory, Breeding Base Eco-Environment and Bio-Ressource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400700, China. Electronic address: georgex@swu.edu.cn.

PMID: 34861432
DOI: 10.1016/j.meegid.2021.105166

Abstract

Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or subsequent death emerging from these infections are frequently connected with cytokine storm. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis. Therefore, there is a need to research some new therapeutic approaches to block IL-6 signaling that are right now being applied to the M. tuberculosis. In this review, we investigate the implication of IL-6 in the context of tuberculosis research.

Keywords: Cytokine storm; Immune response and IL-6; Tuberculosis.

Publication types

Review

MeSH terms

Animals
Cytokine Release Syndrome*
Humans
Interleukin-6 / immunology*
Mice
Tuberculosis / immunology*

Substances

IL6 protein, human
Interleukin-6