Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

Murilo S de Abreu; Ana C V V Giacomini; Rafael Genario; Konstantin A Demin; Tamara G Amstislavskaya; Fabiano Costa; Denis B Rosemberg; Lynne U Sneddon; Tatyana Strekalova; Marta C Soares; Allan V Kalueff

doi:10.1016/j.neulet.2021.136382

Understanding early-life pain and its effects on adult human and animal emotionality: Translational lessons from rodent and zebrafish models

Neurosci Lett. 2022 Jan 18:768:136382. doi: 10.1016/j.neulet.2021.136382. Epub 2021 Nov 30.

Authors

Affiliations

¹ Bioscreening Platform, School of Pharmacy, Southwest University, Chongqing, China; Bioscience Institute, University of Passo Fundo, Passo Fundo, RS, Brazil; Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.
² Bioscience Institute, University of Passo Fundo, Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo, Passo Fundo, RS, Brazil.
³ Bioscience Institute, University of Passo Fundo, Passo Fundo, RS, Brazil.
⁴ Institute of Experimental Medicine, Almazov National Medcial Research Center, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Granov Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
⁵ Scientific Research Institute of Neuroscience and Medicine, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
⁶ Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, Brazil; Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
⁷ Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
⁸ University of Gothenburg, Department of Biological and Environmental Sciences, Gothenburg, Sweden.
⁹ Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine and Department of Normal Physiology, Sechenov 1st Moscow State Medical University, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia; Department of Preventive Medicine, Maastricht Medical Center Annadal, Maastricht, Netherlands.
¹⁰ CIBIO, Research Centre in Biodiversity and Genetic Resources, University of Porto, Campus Agrário de Vairão, Vairão, Portugal.
¹¹ School of Pharmacy, Southwest University, Chongqing, China; Ural Federal University, Ekaterinburg, Russia; Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia. Electronic address: avkalueff@gmail.com.

PMID: 34861343
DOI: 10.1016/j.neulet.2021.136382

Abstract

Critical for organismal survival, pain evokes strong physiological and behavioral responses in various sentient species. Clinical and preclinical (animal) studies markedly increase our understanding of biological consequences of developmental (early-life) adversity, as well as acute and chronic pain. However, the long-term effects of early-life pain exposure on human and animal emotional responses remain poorly understood. Here, we discuss experimental models of nociception in rodents and zebrafish, and summarize mounting evidence of the role of early-life pain in shaping emotional traits later in life. We also call for further development of animal models to probe the impact of early-life pain exposure on behavioral traits, brain disorders and novel therapeutic treatments.

Keywords: Animal models; Behavior; Early-life exposure; Emotional response; Pain.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adverse Childhood Experiences*
Animals
Disease Models, Animal*
Emotions*
Humans
Pain*
Personality
Rodentia
Translational Research, Biomedical*
Zebrafish