GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures

Sci Immunol. 2021 Dec 3;6(66):eabn3790. doi: 10.1126/sciimmunol.abn3790. Epub 2021 Dec 3.

Authors

Gianvito Masi¹, Kevin C O'Connor¹

Affiliation

¹ Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

PMID: 34860582
DOI: 10.1126/sciimmunol.abn3790

Abstract

Epileptic seizures can be mediated by patient autoantibodies targeting ion channels expressed in the brain.

Publication types

Comment

MeSH terms

Autoantibodies*
Humans
Receptors, Neurotransmitter
Seizures*
gamma-Aminobutyric Acid

Substances

Autoantibodies
Receptors, Neurotransmitter
gamma-Aminobutyric Acid