Move over NAIP, DDX17 diversifies the NLRC4 inflammasome

Katherine C Barnett; Kaixin Liang; Jenny P-Y Ting

doi:10.1126/sciimmunol.abm1201

Move over NAIP, DDX17 diversifies the NLRC4 inflammasome

Sci Immunol. 2021 Dec 3;6(66):eabm1201. doi: 10.1126/sciimmunol.abm1201. Epub 2021 Dec 3.

Authors

Katherine C Barnett^{1

2}, Kaixin Liang^{1

2

3}, Jenny P-Y Ting^{1

2

4}

Affiliations

¹ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
³ Oral and Craniofacial Biomedicine Program, Adam School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴ Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 34860580
DOI: 10.1126/sciimmunol.abm1201

Abstract

DDX17 binds short interspersed nuclear element RNAs to nucleate a dual NLRC4/NLRP3 inflammasome, highlighting the emerging role of endogenous ligands in NLRC4 activation (see the related Research Article by Wang et al.).

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

CARD Signaling Adaptor Proteins
Calcium-Binding Proteins
Immunity, Innate
Inflammasomes* / metabolism
Neuronal Apoptosis-Inhibitory Protein* / metabolism

Substances

CARD Signaling Adaptor Proteins
Calcium-Binding Proteins
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein

Grants and funding

T32 CA071341/CA/NCI NIH HHS/United States