The presently ongoing pandemic of human SARS-CoV-2 infections (COVID-19) presents an enormous challenge in surveillance, vaccine and antiviral drug development. Here we report the synthesis of new bioactive quinoline-morpholine hybrid compounds and their virological evaluation, which proves pronounced cell culture-based inhibitory profile against SARS-CoV-2. Thus, selected quinoline compounds may suggest specific hit-to-lead development.
Keywords: SARS-CoV-2; antiviral drug assessment; cell culture-based infection models; morpholine-quinoline hybrids; quinoline compounds.
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.