Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections

Somaye Rashki; Neda Shakour; Zahra Yousefi; Marzieh Rezaei; Mina Homayoonfal; Ehsan Khabazian; Fatemeh Atyabi; Fatemeh Aslanbeigi; Rouzita Safaei Lapavandani; Samaneh Mazaheri; Michael R Hamblin; Hamed Mirzaei

doi:10.3389/fbioe.2021.732461

Cellulose-Based Nanofibril Composite Materials as a New Approach to Fight Bacterial Infections

Front Bioeng Biotechnol. 2021 Nov 11:9:732461. doi: 10.3389/fbioe.2021.732461. eCollection 2021.

Authors

Somaye Rashki¹, Neda Shakour^{2

3}, Zahra Yousefi⁴, Marzieh Rezaei⁵, Mina Homayoonfal⁶, Ehsan Khabazian⁷, Fatemeh Atyabi^{7

8}, Fatemeh Aslanbeigi^{9

10}, Rouzita Safaei Lapavandani¹¹, Samaneh Mazaheri¹², Michael R Hamblin¹³, Hamed Mirzaei⁶

Affiliations

¹ Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
² Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran.
⁵ Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
⁷ Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁸ Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁹ School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
¹⁰ Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
¹¹ Department of Gynecology and Obsteterics, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
¹² Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.
¹³ Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa.

Abstract

Antibiotic resistant microorganisms have become an enormous global challenge, and are predicted to cause hundreds of millions of deaths. Therefore, the search for novel/alternative antimicrobial agents is a grand global challenge. Cellulose is an abundant biopolymer with the advantages of low cost, biodegradability, and biocompatibility. With the recent growth of nanotechnology and nanomedicine, numerous researchers have investigated nanofibril cellulose to try to develop an anti-bacterial biomaterial. However, nanofibril cellulose has no inherent antibacterial activity, and therefore cannot be used on its own. To empower cellulose with anti-bacterial properties, new efficient nanomaterials have been designed based on cellulose-based nanofibrils as potential wound dressings, food packaging, and for other antibacterial applications. In this review we summarize reports concerning the therapeutic potential of cellulose-based nanofibrils against various bacterial infections.

Keywords: antimicrobial activity; bacterial infections; cellulose; nanofibrils; nanotechnology.

Publication types

Review