Fast diffuse correlation spectroscopy with a low-cost, fiber-less embedded diode laser

Biomed Opt Express. 2021 Oct 4;12(11):6686-6700. doi: 10.1364/BOE.435136. eCollection 2021 Nov 1.

Abstract

Diffuse correlation spectroscopy (DCS), a popular optical technique for fast noninvasive measurement of blood flow, is commonly implemented using expensive fiber-coupled long coherence length laser systems. Here, we report the development of a portable and fiber-less approach that can be used as a low-cost alternative to illuminate tissue in DCS instruments. We validate the accuracy and noise characteristics of the fiber-less DCS laser source, by comparisons against traditional DCS light sources, with experiments on controlled tissue-simulating phantoms and in humans.