Facile synthesis of neodymium stannate nanoparticles an effective electrocatalyst for the selective detection of dimetridazole in biological samples

Abstract

In this work, pyrochlore neodymium stannate nanoparticles (Nd₂Sn₂O₇ NP) have been synthesized by a facile co-precipitation technique and employed as an electrode material on GCE for the determination of dimetridazole (DM) drug. The physical properties and texture of the Nd₂Sn₂O₇ NP were characterized by PXRD, Raman spectroscopy, FE-SEM, EDX mapping, XPS, and HR-TEM analytical studies. The electrocatalytic investigation of Nd₂Sn₂O₇ NP/GCE was carried out by CV, and DPV techniques. The fabricated Nd₂Sn₂O₇ NP/GCE shows a lower LOD of 6 nm towards the determination of DM and the calculated sensitivity is 0.61 μA μM^-1 cm^-2. In addition to that, the constructed sensor delivers notable repeatability, reproducibility, and superior selectivity with the existence of metal ions, biological molecules, and nitro compounds, enabling the electrochemical detection of DM. Furthermore, Nd₂Sn₂O₇ NP/GCE sensor displays acceptable recovery results in the real sample analysis in biological fluids such as human blood serum and human urine.

Keywords: Biological samples; Dimetridazole detection; Electrochemical sensor; Nd(2)Sn(2)O(7).