Antioxidants as modulators of arsenic-induced oxidative stress tolerance in plants: An overview

Abstract

Arsenic (As) is a highly toxic contaminant in the environment. Although both inorganic and organic types of arsenic exist in the environment, the most common inorganic forms of As that adversely affect plants are arsenite (As III) and arsenate (As V). Despite no evidence for As being essential for plant growth, exposure of roots to this element can cause its uptake primarily via transporters responsible for the transport of essential mineral nutrients. Arsenic exposure even at low concentrations disturbs the plant normal functioning via excessive generation of reactive oxygen species, a condition known as oxidative stress leading to an imbalance in the redox system of the plant. This is associated with considerable damage to the cell components thereby impairing normal cellular functions and activation of several cell survival and cell death pathways. To counteract this oxidative disorder, plants possess natural defense mechanisms such as chemical species and enzymatic antioxidants. This review considers how different types of antioxidants participate in the oxidative defense mechanism to alleviate As stress in plants. Since the underlying phenomena of oxidative stress tolerance are not yet fully elucidated, the potential for "Omics" technologies to uncover molecular mechanisms are discussed. Various strategies to improve As-induced oxidative tolerance in plants such as exogenous supplementation of effective growth regulators, protectant chemicals, transgenic approaches, and genome editing are also discussed thoroughly in this review.

Keywords: Antioxidants; CRISPR; Heavy metals; Omics; Phytotoxicity; Reactive oxygen species.