Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels

Jonathan Douxfils; Caroline Vayne; Claire Pouplard; Thomas Lecompte; Julien Favresse; Florence Potier; Emy Gasser; Valérie Mathieux; Jean-Michel Dogné; Yves Gruel; Jérôme Rollin; François Mullier

doi:10.3324/haematol.2021.279509

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels

Haematologica. 2021 Dec 1;106(12):3249-3252. doi: 10.3324/haematol.2021.279509.

Authors

Affiliations

¹ University of Namur, Department of Pharmacy, Namur Research for Life Sciences, Namur Thrombosis and Hemostasis Center, Namur, Belgium; QUALIblood s.a., Namur. jonathan.douxfils@unamur.be.
² University of Tours, EA7501 GICC, CHRU de Tours, Department of Haemostasis, Tours.
³ Département de Médecine, Hôpitaux Universitaires de Genève, service d'angiologie et d'hémostase et Faculté de Médecine, Geneva Platelet Group (GpG), Université de Genève, Geneva.
⁴ University of Namur, Department of Pharmacy, Namur Research for Life Sciences, Namur Thrombosis and Hemostasis Center, Namur, Belgium; Clinique Saint-Luc Bouge, Department of Laboratory Medicine, Bouge.
⁵ Service de gériatrie, CHU UCL Namur site Sainte-Elisabeth, Namur.
⁶ Université Catholique de Louvain, service de gériatrie, CHU UCL Namur site Sainte-Elisabeth, Namur.
⁷ CHU UCL Namur | site Sainte-Elizabeth, Université catholique de Louvain, Department of Hematology, Namur Research Institute for Life Sciences, Namur Thrombosis and Hemostasis Center, Yvoir.
⁸ University of Namur, Department of Pharmacy, Namur Research for Life Sciences, Namur Thrombosis and Hemostasis Center, Namur.
⁹ Université catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center, Hematology Laboratory, Namur Research Institute for Life Sciences, Yvoir.

No abstract available

MeSH terms

Humans
Immunoglobulins, Intravenous
Leukopenia*
Thrombocytopenia* / chemically induced
Thrombocytopenia* / diagnosis
Thrombocytopenia* / drug therapy
Thrombosis*
Vaccination

Substances

Immunoglobulins, Intravenous

Grants and funding

Informed consent and ethical committee approval: as the patient died, an independent Review Board of the Clinique Sainte-Elisabeth CHU UCL Namur (OM070) was consulted to decide if reporting this case is ethically acceptable. This Ethical Committee (decision number: 27-21) was in favor of the publication of this case and did not see any ethical issue in publishing this case report. All data has been anonymized.