Diabetic hypertriglyceridaemia and Alzheimer's disease: causal or not?

Curr Opin Endocrinol Diabetes Obes. 2022 Apr 1;29(2):101-105. doi: 10.1097/MED.0000000000000696.

Abstract

Purpose of review: To summarize recent findings considering type II diabetes, or metabolic syndrome dyslipidaemia with risk for Alzheimer's disease.

Recent findings: Population, genetic, clinical and preclinical studies support the hypothesis of increased risk for Alzheimer's disease in type 2 diabetes mellitus. The mechanisms are unclear. However, recent studies suggest that aberrations in the peripheral metabolism of triglyceride-rich-lipoproteins compromise the brain microvasculature.

Summary: We review the literature of prediabetic metabolic syndrome and type 2 diabetes mellitus as a risk factor for Alzheimer's disease. We focus on a potential association with aberrations in the systemic metabolism of triglyceride-rich-lipoproteins reported over 18 months.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease* / complications
  • Diabetes Mellitus, Type 2* / complications
  • Diabetes Mellitus, Type 2* / metabolism
  • Humans
  • Hyperlipidemias* / complications
  • Hypertriglyceridemia* / complications
  • Lipoproteins / metabolism
  • Metabolic Syndrome* / complications
  • Triglycerides

Substances

  • Lipoproteins
  • Triglycerides