Natural ingredients from Chinese materia medica for pulmonary hypertension

Jia-Rui Zhang; Xuan Ouyang; Chi Hou; Qi-Feng Yang; Yingjun Wu; Wen-Ju Lu; Chun-Li Liu; Kai Yang; Nan-Shan Zhong; Jian Wang; Yu-Qin Chen

doi:10.1016/S1875-5364(21)60092-4

Natural ingredients from Chinese materia medica for pulmonary hypertension

Chin J Nat Med. 2021 Nov;19(11):801-814. doi: 10.1016/S1875-5364(21)60092-4.

Authors

Jia-Rui Zhang¹, Xuan Ouyang¹, Chi Hou², Qi-Feng Yang¹, Yingjun Wu³, Wen-Ju Lu¹, Chun-Li Liu¹, Kai Yang¹, Nan-Shan Zhong¹, Jian Wang⁴, Yu-Qin Chen⁵

Affiliations

¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
² State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China; Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou 510000, China.
³ The Second Affiliated Hospital of Guangzhou medical university, 250 Changgangdong Rd, Guangzhou 51026, China.
⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China; Division of Pulmonary and Critical Care Medicine, the People's Hospital of Inner Mongolia, Huhhot 010000, China; Section of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego 92173, USA. Electronic address: jiw037@ucsd.edu.
⁵ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China. Electronic address: yqchen@gzhmu.edu.cn.

PMID: 34844719
DOI: 10.1016/S1875-5364(21)60092-4

Abstract

Pulmonary hypertension (PH) is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure, which may eventually develop to right heart failure and death. Although newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH, limited types of effective and economical drugs for PH still makes it as a life-threatening disease. Some drugs from Chinese materia medica (CMM) have been traditionally applied in the treatment of lung diseases. Accumulating evidence suggests active pharmaceutical ingredients (APIs) derived from those medicines brings promising future for the prevention and treatment of PH. In this review, we summarized the pharmacological effects of APIs derived from CMM which are potent in treating PH, so as to provide new thoughts for initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.

Keywords: Active pharmaceutical ingredients; Chinese materia medica; Pulmonary hypertension.

Publication types

Review

MeSH terms

China
Drugs, Chinese Herbal*
Humans
Hypertension, Pulmonary* / drug therapy
Materia Medica*
Medicine, Chinese Traditional

Substances

Drugs, Chinese Herbal
Materia Medica