Information and the single cell

Abstract

Understanding the evolution of cognition requires an understanding of the costs and benefits of neural computation. This requires analysis of neuronal circuitry in terms of information-processing efficiency, ultimately cashed out in terms of ATP expenditures relative to adaptive problem-solving abilities. Despite a preoccupation in neuroscience with the synapse as the source of stored neural information, it is clear that, along with synaptic weights and electrochemical dynamics, neurons have multiple mechanisms which store and process information, including 'wetware' (protein phosphorylation, gene transcription, and so on) and cell morphology (dendritic form). Insights into non-synaptic information-processing can be gained by examining the surprisingly complex abilities of single-celled organisms ('cellular cognition') because neurons share many of the same abilities. Cells provide the fundamental level at which information processing interfaces with gene expression, and cell-internal information-processing mechanisms are both powerful and energetically efficient. Understanding cellular computation should be a central goal of research on cognitive evolution.