Emerging roles for AQP in mammalian extracellular vesicles

Abstract

Recent research in the aquaporin (AQP) field has identified a role for diverse AQPs in extracellular vesicles (EV). Though still in its infancy, there is a growing body of knowledge in the area; AQPs in EV have been suggested as biomarkers for disease, as drug targets and show potential as therapeutics. To advance further in this field, AQPs in EV must be better understood. Here we summarize current knowledge of the presence and function of AQPs in EV and hypothesise their roles in health and disease.

Keywords: Aquaporin; Exosome; Extracellular vesicle; Inflammation; Microvesicle; Oedema; Signalling; Water channel.