Studies on the phytochemical constituents of Smilax elegantissima Gagnep

Nat Prod Res. 2023 Apr;37(8):1365-1371. doi: 10.1080/14786419.2021.2010072. Epub 2021 Nov 28.

Abstract

Nine compounds were isolated and elucidated from this species, among which, two new compounds (1, 2) and seven known compounds (3-9). Their structures were determined by means of extensively spectroscopic analysis including HR-ESI-MS, 1H NMR, 13C NMR, HSQC and HMBC. The bioactivities evaluation was referred to the cytotoxic assay on four human tumor cell lines of the ethanol extract, different fractions and 6 compounds. The results demonstrated that the dichloromethane fraction showed the strongest cytotoxicity, followed by the ethyl acetate fraction. Compounds 4 and 6 had significant effects on SMMC-7721 and Hela cells.

Keywords: S. elegantissima Gagnep.; cytotoxicity; phytochemical composition; tumor cells.

MeSH terms

  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • HeLa Cells
  • Humans
  • Phytochemicals / analysis
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Smilax* / chemistry

Substances

  • Antineoplastic Agents
  • Phytochemicals
  • Plant Extracts