Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

Kristyna Maleninska; Martina Janikova; Dominika Radostova; Iveta Vojtechova; Tomas Petrasek; Denisa Kirdajova; Miroslava Anderova; Jan Svoboda; Ales Stuchlik

doi:10.1016/j.bbr.2021.113678

Selective deficits in attentional set-shifting in mice induced by maternal immune activation with poly(I:C)

Behav Brain Res. 2022 Feb 15:419:113678. doi: 10.1016/j.bbr.2021.113678. Epub 2021 Nov 25.

Authors

Kristyna Maleninska¹, Martina Janikova², Dominika Radostova³, Iveta Vojtechova⁴, Tomas Petrasek⁴, Denisa Kirdajova⁵, Miroslava Anderova⁵, Jan Svoboda³, Ales Stuchlik⁶

Affiliations

¹ Laboratory of the Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic; National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.
² Laboratory of the Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic; First Faculty of Medicine, Charles University, Prague, Czech Republic.
³ Laboratory of the Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic.
⁴ Laboratory of the Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic; National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.
⁵ Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic.
⁶ Laboratory of the Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic. Electronic address: Ales.Stuchlik@fgu.cas.cz.

PMID: 34838932
DOI: 10.1016/j.bbr.2021.113678

Abstract

Maternal immune activation has been identified as a significant risk factor for schizophrenia. Using rodent models, past work has demonstrated various behavioral and brain impairments in offspring after immune-activating events. We applied 5 mg/kg of poly(I:C) on gestation day 9 to pregnant mouse dams, whose offspring were then stressed during puberty. We show impairments in attentional set-shifting in a T-maze, and a decreased number of parvalbumin-positive interneurons in the hippocampus as a result of peripubertal stress specifically in females.

Keywords: Behavioral tests; Cognitive deficit; Immunochallenge; Interneurons; Maternal immune activation; Mouse; Poly(I:C); Prenatal infection; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Attention / physiology*
Behavior, Animal / physiology
Cognitive Dysfunction / etiology
Cognitive Dysfunction / pathology
Cognitive Dysfunction / physiopathology*
Disease Models, Animal
Executive Function / physiology*
Female
Hippocampus / cytology
Interneurons / cytology
Male
Mice
Mice, Inbred C57BL
Poly I-C / administration & dosage
Pregnancy
Pregnancy Complications, Infectious* / chemically induced
Pregnancy Complications, Infectious* / immunology
Prenatal Exposure Delayed Effects / chemically induced
Prenatal Exposure Delayed Effects / pathology
Prenatal Exposure Delayed Effects / physiopathology*
Schizophrenia / etiology
Schizophrenia / immunology
Schizophrenia / pathology
Schizophrenia / physiopathology*
Stress, Psychological / complications
Stress, Psychological / pathology
Stress, Psychological / physiopathology*

Substances

Poly I-C