How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity

Laurie-Anne Lamotte; Lionel Tafforeau

doi:10.3390/v13112309

How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity

Viruses. 2021 Nov 19;13(11):2309. doi: 10.3390/v13112309.

Authors

Laurie-Anne Lamotte¹, Lionel Tafforeau¹

Affiliation

¹ Cell Biology Laboratory, Research Institute for Biosciences, Research Institute for Health Sciences and Technology, University of Mons, 7000 Mons, Belgium.

Abstract

Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host's antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.

Keywords: ISG; NEDD8; NS1; RIG-I; SUMO; TRIM25; cytokines; influenza A virus; innate immunity; interferon; ubiquitin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Immunity, Innate
Influenza A virus / immunology*
Influenza, Human* / immunology
Influenza, Human* / virology
Orthomyxoviridae Infections* / immunology
Orthomyxoviridae Infections* / virology
Ubiquitin / immunology*
Viral Nonstructural Proteins / immunology*

Substances

INS1 protein, influenza virus
Ubiquitin
Viral Nonstructural Proteins