Interaction of Alcohol Consumption and ABCG2 rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population

I-Chieh Chen; Yen-Ju Chen; Yi-Ming Chen; Hsueh-Ju Lin; Ying-Cheng Lin; Jui-Chun Chagn; Pei-Chun Chen; Ching-Heng Lin

doi:10.3390/jpm11111158

Interaction of Alcohol Consumption and ABCG2 rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population

J Pers Med. 2021 Nov 7;11(11):1158. doi: 10.3390/jpm11111158.

Authors

I-Chieh Chen¹, Yen-Ju Chen^{1

2

3}, Yi-Ming Chen^{1

2

4

5}, Hsueh-Ju Lin¹, Ying-Cheng Lin⁶, Jui-Chun Chagn⁷, Pei-Chun Chen⁸, Ching-Heng Lin^{1

9

10

11

12

13}

Affiliations

¹ Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
² Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
³ Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei City 11221, Taiwan.
⁴ Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402202, Taiwan.
⁵ School of Medicine, National Yang Ming Chiao Tung University, Taipei City 11221, Taiwan.
⁶ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
⁷ Department of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
⁸ Department of Mathematics and Information Education, National Taipei University of Education, Taipei City 10671, Taiwan.
⁹ Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
¹⁰ Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei City 112303, Taiwan.
¹¹ Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 40704, Taiwan.
¹² Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University, Taipei City 11221, Taiwan.
¹³ Department of Internal Medicine, China Medical University Hospital, Taichung 404332, Taiwan.

Abstract

Background: ABCG2 rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2 gene) together, contribute to enhanced serum uric acid levels. However, the interaction between ABCG2 rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with ABCG2 rs2231142 variants and how this is affected by alcohol consumption.

Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between ABCG2 rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models.

Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of ABCG2 rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of ABCG2 rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women.

Conclusion: the ABCG2 rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the ABCG2 rs2231142 risk allele contributes to increased HUA risk.

Keywords: ABCG2 rs2231142; alcohol consumption; hyperuricemia; serum uric acid levels.

Grants and funding

TCVGH-NHRI10901/Taichung Veterans General Hospital