A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

Essa M Saied; Yousra A El-Maradny; Alaa A Osman; Amira M G Darwish; Hebatallah H Abo Nahas; Gniewko Niedbała; Magdalena Piekutowska; Mohamed A Abdel-Rahman; Bassem A Balbool; Ahmed M Abdel-Azeem

doi:10.3390/pharmaceutics13111759

A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

Pharmaceutics. 2021 Oct 21;13(11):1759. doi: 10.3390/pharmaceutics13111759.

Authors

Affiliations

¹ Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
² Institute for Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany.
³ Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt.
⁴ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, New Giza University, Newgiza, km 22 Cairo-Alexandria Desert Road, Cairo 12256, Egypt.
⁵ Food Technology Department, Arid Lands Cultivation Research Institute (ALCRI), City of Scientific Research and Technological Applications (SRTA City), Alexandria 21934, Egypt.
⁶ Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
⁷ Department of Biosystems Engineering, Faculty of Environmental and Mechanical Engineering, Poznań University of Life Sciences, Wojska Polskiego 50, 60-627 Poznań, Poland.
⁸ Department of Geoecology and Geoinformation, Institute of Biology and Earth Sciences, Pomeranian University in Słupsk, Partyzantów 27, 76-200 Słupsk, Poland.
⁹ Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza 12585, Egypt.
¹⁰ Botany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.

Abstract

In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of Coronaviridae. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes. This review presents the classification and a detailed explanation of the SARS-CoV-2 molecular characteristics and structure-function relationships. We present all currently available crystal structures of different SARS-CoV-2 proteins and emphasized on the crystal structure of different virus proteins and the binding modes of their ligands. This review also discusses the various therapeutic approaches for COVID-19 treatment and available vaccinations. In addition, we highlight and compare the existing data about natural compounds extracted from algae, fungi, plants, and scorpion venom that were used as antiviral agents against SARS-CoV-2 infection. Moreover, we discuss the repurposing of select approved therapeutic agents that have been used in the treatment of other viruses.

Keywords: COVID-19; SARS-CoV-2; antioxidants; antivirals; coronavirus; molecular structure; natural products; therapeutic approach; vaccines; virus detection; virus lifecycle.

Publication types

Review