Glycine Transporters and Receptors as Targets for Analgesics

Robert J Harvey; Robert J Vandenberg

doi:10.3390/biom11111676

Glycine Transporters and Receptors as Targets for Analgesics

Biomolecules. 2021 Nov 11;11(11):1676. doi: 10.3390/biom11111676.

Authors

Robert J Harvey^{1

2}, Robert J Vandenberg³

Affiliations

¹ School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore, QLD 4556, Australia.
² Sunshine Coast Health Institute, Birtinya, QLD 4558, Australia.
³ School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.

Abstract

The suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain has gained widespread recognition, with glycine receptors (GlyRs) and glycine transporters (GlyT1 and GlyT2) now considered key therapeutic targets [...].

Publication types

Editorial
Comment

MeSH terms

Analgesics / pharmacology
Glycine
Glycine Plasma Membrane Transport Proteins* / genetics
Glycine Plasma Membrane Transport Proteins* / metabolism
Receptors, Glycine / genetics
Synaptic Transmission*

Substances

Analgesics
Glycine Plasma Membrane Transport Proteins
Receptors, Glycine
Glycine