Bioactive cytochalasans from the fungus Arthrinium arundinis DJ-13

Yan Shu; Jia-Peng Wang; Bing-Xian Li; Jun-Li Gan; Hao Ding; Rui Liu; Le Cai; Zhong-Tao Ding

doi:10.1016/j.phytochem.2021.113009

Bioactive cytochalasans from the fungus Arthrinium arundinis DJ-13

Phytochemistry. 2022 Feb:194:113009. doi: 10.1016/j.phytochem.2021.113009. Epub 2021 Nov 23.

Authors

Yan Shu¹, Jia-Peng Wang¹, Bing-Xian Li¹, Jun-Li Gan¹, Hao Ding¹, Rui Liu¹, Le Cai², Zhong-Tao Ding³

Affiliations

¹ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.
² Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. Electronic address: caile@ynu.edu.cn.
³ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. Electronic address: ztding@ynu.edu.cn.

PMID: 34826796
DOI: 10.1016/j.phytochem.2021.113009

Abstract

The investigation of the metabolites from Arthrinium arundinis DJ-13 grown in solid medium revealed six undescribed cytochalasans, arundisins A-F and twelve known compounds. Their structures were initially investigated in detail by spectroscopic analyses and were further confirmed by X-crystallography and ECD experiments. In the in vitro bioassays, arundisins A and B showed cytotoxic activity against the MCF-7 breast cancer cell line with IC₅₀ values of 18.82 ± 0.36 and 15.20 ± 0.42 μM, respectively. Arundisin F exhibited potent antibacterial activity against Escherichia coli with MIC of 8.00 μg/mL (kanamycin, 2.00 μg/mL), and arundisin D displayed gently antibacterial activity against Candida albicans with MIC of 32.00 μg/mL (Nystatin, 1.00 μg/mL).

Keywords: Antibacterial activity; Apiosporaceae; Arthrinium arundinis; Arundisin; Cytochalasan; Cytotoxicity.

MeSH terms

Ascomycota*
Candida albicans
Cytochalasins
Escherichia coli

Substances

Cytochalasins

Supplementary concepts

Arthrinium arundinis