Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons

Elizaveta A Dutysheva; Irina A Utepova; Maria A Trestsova; Alexander S Anisimov; Valery N Charushin; Oleg N Chupakhin; Boris A Margulis; Irina V Guzhova; Vladimir F Lazarev

doi:10.1016/j.dib.2021.107562

Dataset of NMR-spectra pyrrolyl- and indolylazines and evidence of their ability to induce heat shock genes expression in human neurons

Data Brief. 2021 Nov 12:39:107562. doi: 10.1016/j.dib.2021.107562. eCollection 2021 Dec.

Authors

Affiliations

¹ Russian Academy of Sciences, Institute of Cytology, St. Petersburg 194064, Russia.
² Ural Federal University, Ekaterinburg 620002, Russia.
³ Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia.

Abstract

These data are related to our previous paper "Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease" (Dutysheva et al., 2021), in which we demonstrate neuroprotective abilities of pyrrolyl- and indolylazines in a cell model of Alzheimer's disease. Using a novel procedure of photocatalysis we have synthesized a group of new compounds. The current article presents nuclear magnetic resonance spectra including heteronuclear single quantum coherence spectra of chemicals synthesized by us. The effect of new compounds have on heat shock proteins genes expression in reprogrammed human neurons are presented. We also presented data that verify neuronal phenotype of reprogrammed cells.

Keywords: Green chemistry; Heat shock genes; Indolylazines; Nuclear magnetic resonance; Photocatalysis; Pyrrolylazines.