Anaphylaxis to Drugs, Biological Agents, and Vaccines

Ruchi H Shah; Margaret M Kuder; David M Lang

doi:10.1016/j.iac.2021.10.001

Anaphylaxis to Drugs, Biological Agents, and Vaccines

Immunol Allergy Clin North Am. 2022 Feb;42(1):121-144. doi: 10.1016/j.iac.2021.10.001.

Authors

Ruchi H Shah¹, Margaret M Kuder¹, David M Lang²

Affiliations

¹ Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic.
² Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic. Electronic address: LANGD@ccf.org.

PMID: 34823742
DOI: 10.1016/j.iac.2021.10.001

Abstract

Anaphylaxis is a multi-system syndrome resulting from the release of mediators from mast cells and basophils. Drugs are common causes. Anaphylaxis to certain drugs, vaccines, and biological agents present clinical challenges, and merit referral to a board-certified allergist/immunologist for further evaluation and management.

Keywords: Anaphylaxis; Aspirin-exacerbated respiratory disease; Contrast-induced anaphylaxis; Drug-induced anaphylaxis; NSAID-Induced anaphylaxis; Vaccine-induced anaphylaxis.

Publication types

Review

MeSH terms

Anaphylaxis*
Basophils
Biological Factors
Humans
Pharmaceutical Preparations*
Vaccines* / adverse effects

Substances

Biological Factors
Pharmaceutical Preparations
Vaccines