Analysis and Sequence Alignment of Peste des Petits Ruminants Virus ChinaSX2020

Lingxia Li; Jinyan Wu; Xiaoan Cao; Jijun He; Xiangtao Liu; Youjun Shang

doi:10.3390/vetsci8110285

Analysis and Sequence Alignment of Peste des Petits Ruminants Virus ChinaSX2020

Vet Sci. 2021 Nov 22;8(11):285. doi: 10.3390/vetsci8110285.

Authors

Lingxia Li¹, Jinyan Wu¹, Xiaoan Cao¹, Jijun He¹, Xiangtao Liu¹, Youjun Shang¹

Affiliation

¹ State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.

Abstract

The peste des petits ruminants virus (PPRV) mainly infects goats and sheep and causes a highly contagious disease, PPR. Recently, a PPRV strain named ChinaSX2020 was isolated and confirmed following an indirect immunofluorescence assay and PCR using PPRV-specific antibody and primers, respectively. A sequencing of the ChinaSX2020 strain showed a genome length of 15,954 nucleotides. A phylogenetic tree analysis showed that the ChinaSX2020 genome was classified into lineage IV of the PRRV genotypes. The genome of the ChinaSX2020 strain was found to be closely related to PPRVs isolated in China between 2013 and 2014. These findings revealed that not a variety of PRRVs but similar PPRVs were continuously spreading and causing sporadic outbreaks in China.

Keywords: ChinaSX2020; PPRV; genome; sequence alignment.