Fatal thiopurine toxicity: pre-emptive testing of NUDT15 415C> T polymorphism may be life saving in South Asian population

Drug Metab Pers Ther. 2021 May 4;36(4):351-352. doi: 10.1515/dmpt-2021-0120.

Authors

Amit Yadav¹, Anuraag Jena¹, Rozy Thakur², Pankaj Kumar¹, Prateek Bhatia², Vishal Sharma¹

Affiliations

¹ Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 34821123
DOI: 10.1515/dmpt-2021-0120

No abstract available

Keywords: Nudix hydrolase 15; inflammatory bowel disease; myelosuppression; thiopurines; ulcerative colitis.

Publication types

Case Reports
Letter

MeSH terms

Asian People* / genetics
Azathioprine / poisoning*
Humans
Polymorphism, Genetic*
Pyrophosphatases / genetics*

Substances

NUDT15 protein, human
Pyrophosphatases
Azathioprine