Flavonoids are a large class of compounds that are widely found in many plants, including plants used in Chinese herbal medicines. Previous studies have revealed that flavonoids possess biomedical activities, including antioxidant, anti-cancer, anti-viral, and anti-inflammatory properties. They also have the functions of lowering lipids, lowering blood sugar, and improving insulin resistance. This article selects four typical compounds of flavonoids, namely baicalin, baicalein, quercetin, and rutin, and reviews their effects and mechanisms of action in improving insulin resistance. With a view for future clinical research on flavonoids as antidiabetic drugs, we therefore provide the theoretical basis for the development and application of flavonoids.
Keywords: baicalein; baicalin; flavonoids; insulin resistance; quercetin; rutin; type 2 diabetes.
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