Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

Yajun Li; Kailin Chen; Chaohui Zuo; Ruolan Zeng; Yizi He; Xiaoyan Chen; Ling Xiao; Hui Zhou

doi:10.2147/IJGM.S335464

Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

Int J Gen Med. 2021 Nov 17:14:8399-8411. doi: 10.2147/IJGM.S335464. eCollection 2021.

Authors

Yajun Li¹, Kailin Chen², Chaohui Zuo³, Ruolan Zeng¹, Yizi He¹, Xiaoyan Chen⁴, Ling Xiao⁵, Hui Zhou¹

Affiliations

¹ Department of Lymphoma and Hematology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, People's Republic of China.
² Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 510060, People's Republic of China.
³ Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School and Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
⁴ Department of Pathology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
⁵ Department of Histology and Embryology, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, People's Republic of China.

Abstract

Purpose: Hepatosplenic T cell lymphoma (HSTCL) is a rare tumor that lacks data to guide management decisions. To shed light on the nature and therapy of the entity, we conducted this study.

Patients and methods: We retrospectively reviewed patients diagnosed with HSTCL between 1975 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database to analyze the clinical characteristics and survival outcome compared with PTCL-NOS and ALK+ ALCL.

Results: A total of 123 HSTCLs were included in the analysis. Most patients were aged ≤60 years (81.3%) and had a male predominance (69.1%). Organs with lymphoma infiltration of HSTCL were more common in the spleen (98.4%). The 1-year, 3-year, and 5-year overall survival (OS) rates in the entire HSTCL cohort were 56.9% (95% CI, 47.5-66.3%), 37.6% (95% CI, 28.0-47.2%), and 31.6.0% (95% CI, 22.2-41.0%), respectively. The overall survival (OS) of HSTCL patients was similar to that of PTCL-NOS patients (P = 0.128) but worse than that of patients with ALK+ ALCL (P < 0.001). The disease-specific survival (DSS) of HSTCL patients was worse than that of PTCL-NOS and ALK+ ALCL patients (P < 0.05). The same tendency was found in the matched data set. Cox regression analyses indicated that the use of chemotherapy combined with topical treatment may improve the survival of patients with HSTCL.

Conclusion: A higher proportion of young patients and a strong male predominance were found in HSTCL. Chemotherapy combined with topical treatment may be an optional regimen. Further studies are needed to intensify efforts in dealing with this rare but unfavorable disease.

Keywords: SEER; hepatosplenic T cell lymphoma; survival; treatment.

Grants and funding

This work is supported by Hunan Provincial Natural Science Foundation of China (No. 2021JJ30425), Changsha Municipal Natural Science Foundation (No. kq2014206), the grants from Natural Science Foundation of Hunan Province National Health Commission (No. 20201659), and the grants from the Hunan Provincial Science and Technology Department (No. 2016JJ3083, No. 2017SK2130).