Infection with Clostridioides difficile ribotype 046 in a paediatric liver transplant patient

Hildenia B R Nogueira; Cecília L Costa; Conceição S Martins; Maria Luana G S Morais; Carlos Quesada-Gómez; Cibele B M Carvalho; Eliane de Oliveira Ferreira; Gerly Anne de Castro Brito

doi:10.1099/acmi.0.000268

Infection with Clostridioides difficile ribotype 046 in a paediatric liver transplant patient

Access Microbiol. 2021 Oct 20;3(10):000268. doi: 10.1099/acmi.0.000268. eCollection 2021.

Authors

Affiliations

¹ Albert Sabin Children's Hospital, Fortaleza, Ceara, Brazil.
² Department of Morphology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.
³ University of Fortaleza, CE, Brazil.
⁴ Laboratory of Bacteriology, Department of Pathology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.
⁵ Facultad de Microbiología and Centro de Investigación en Enfermedades Tropicales, Universidad de Costa Rica, San José, Costa Rica.
⁶ Federal University of Rio de Janeiro, Institute of Microbiology Paulo de Góes, Laboratory of Anaerobic Biology, Rio de Janeiro, Brazil.

Abstract

Clostridioides difficile causes nosocomial diarrhoea associated with antibiotic use and immunodeficiency. Although the number of paediatric C. difficile infections (CDIs) has increased worldwide, there are few studies on the molecular characterization of strains causing CDIs among children. We report the clinical features and strain molecular characterization of a CDI in a female child with a history of liver transplantation at 7 months of age. This is the first report of the 046 ribotype causing paediatric diarrhoea.

Keywords: Clostridioides difficile infection; liver transplant; molecular characterisation; paediatric.

Publication types

Case Reports