Cryobiopsy as a reliable technique for the preoperative identification of micropapillary/solid components in early-stage lung adenocarcinoma

Mikito Suzuki; Yuji Matsumoto; Tatsuya Imabayashi; Takashi Teishikata; Takaaki Tsuchida; Hisao Asamura; Yasushi Yatabe

doi:10.1016/j.lungcan.2021.11.004

Cryobiopsy as a reliable technique for the preoperative identification of micropapillary/solid components in early-stage lung adenocarcinoma

Lung Cancer. 2021 Dec:162:147-153. doi: 10.1016/j.lungcan.2021.11.004. Epub 2021 Nov 13.

Authors

Mikito Suzuki¹, Yuji Matsumoto², Tatsuya Imabayashi³, Takashi Teishikata⁴, Takaaki Tsuchida³, Hisao Asamura⁵, Yasushi Yatabe⁴

Affiliations

¹ Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
² Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan. Electronic address: yumatsum@ncc.go.jp.
³ Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
⁴ Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
⁵ Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.

PMID: 34814012
DOI: 10.1016/j.lungcan.2021.11.004

Abstract

Objectives: Micropapillary (MIP) and solid (SOL) subtypes of early-stage lung adenocarcinomas are associated with lymph node metastasis and local recurrence after limited resection. Preoperative identification of these components may influence the decisions of treatment strategy, additional lymph node evaluation, indication for limited resection, and extent of lymph node dissection. However, conventional biopsy specimens are insufficient for identifying these subtypes, especially MIP components. Cryobiopsy can collect larger tissue samples with fewer crush artifacts than conventional forceps biopsy, which would be helpful for detecting MIP/SOL components. Thus, this study aimed to analyze the feasibility of using cryobiopsy for MIP/SOL subtype detection.

Material and methods: Consecutive patients who underwent surgery for clinical IA lung cancer following a preoperative diagnosis of adenocarcinoma by cryobiopsy at our institution between October 2017 and July 2019 were retrospectively examined. The concordance rate of MIP/SOL subtypes between the specimens obtained by cryobiopsy and surgery was investigated.

Results: In total, 115 patients were evaluated. There were 26 (22.6%) and 14 (12.2%) patients with MIP and SOL subtypes, respectively. For concordance of MIP/SOL subtypes, the sensitivity was 65.7% (95% confidence interval [CI]: 57.7-65.7%). For the primary or secondary predominant patterns, a more satisfactory concordance rate of 72.2% (95% CI: 52.6-86.2%) was obtained. On assessing each subtype, high sensitivity was noted in SOL-predominant patterns (85.7%, 95% CI: 56.5%-96.0%) and MIP-secondary predominant patterns (83.3%, 95% CI: 45.8-97.0%). However, SOL-secondary predominant patterns revealed low sensitivity (0%, 95% CI, 0-38.2%). Overall, the MIP subtypes had higher sensitivity than the SOL subtypes (65.4% vs. 50.0%).

Conclusion: Cryobiopsy could be reliable for identifying MIP/SOL components, especially the MIP component, in clinical stage IA adenocarcinomas.

Keywords: Adenocarcinoma; Bronchoscopy; Cryobiopsy; Micropapillary; Solid.

MeSH terms

Adenocarcinoma of Lung* / diagnosis
Adenocarcinoma of Lung* / pathology
Adenocarcinoma* / diagnosis
Adenocarcinoma* / pathology
Adenocarcinoma* / surgery
Humans
Lung Neoplasms* / diagnosis
Lung Neoplasms* / pathology
Lung Neoplasms* / surgery
Lymphatic Metastasis
Neoplasm Staging
Prognosis
Retrospective Studies