Do-It-Yourself Open Artificial Pancreas System in Children and Adolescents with Type 1 Diabetes Mellitus: Real-World Data

Diabetes Metab J. 2022 Jan;46(1):154-159. doi: 10.4093/dmj.2021.0011. Epub 2021 Nov 23.

Abstract

Few studies have been conducted among Asian children and adolescents with type 1 diabetes mellitus (T1DM) using do-it-yourself artificial pancreas system (DIY-APS). We evaluated real-world data of pediatric T1DM patients using DIY-APS. Data were obtained for 10 patients using a DIY-APS with algorithms. We collected sensor glucose and insulin delivery data from each participant for a period of 4 weeks. Average glycosylated hemoglobin was 6.2%±0.3%. The mean percentage of time that glucose level remained in the target range of 70 to 180 mg/dL was 82.4%±7.8%. Other parameters including time above range, time below range and mean glucose were also within the recommended level, similar to previous commercial and DIY-APS studies. However, despite meeting the target range, unadjusted gaps were still observed between the median basal setting and temporary basal insulin, which should be handled by healthcare providers.

Keywords: Algorithms; Diabetes mellitus, type 1; Insulin infusion system; Pancreas, artificial.

MeSH terms

  • Adolescent
  • Child
  • Diabetes Mellitus, Type 1* / drug therapy
  • Glycated Hemoglobin / analysis
  • Humans
  • Insulin / therapeutic use
  • Insulin Infusion Systems
  • Pancreas, Artificial*

Substances

  • Glycated Hemoglobin A
  • Insulin