Dermatology is one of the few visual specialties; much can be seen with the naked eye, yet many tools and devices can facilitate the diagnosis of cutaneous maladies. There has been significant progress in diagnostic techniques in recent decades with the advent of artificial intelligence and teledermatology. Such advancements reflect principles of long-standing aids, whereas others embody novel techniques and concepts. These bedside tools range from simple magnifiers and binocular loupes to reflectance confocal microscopes and ultrasounds. The cornerstone diagnostic techniques, including the potassium hydroxide examination and the Tzanck smear, remain highly useful. Although visual examination often permits an accurate diagnosis of a skin disease, the clinician is now even further equipped. Just as the microscope did 4 centuries ago, newer advances will continue to revolutionize the practice of medicine.
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