Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion

Chonghui Xu; Jizheng Chen; Xinwen Chen

doi:10.3389/fmicb.2021.740464

Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion

Front Microbiol. 2021 Nov 3:12:740464. doi: 10.3389/fmicb.2021.740464. eCollection 2021.

Authors

Chonghui Xu^{1

2}, Jizheng Chen^{1

3}, Xinwen Chen^{1

3}

Affiliations

¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Abstract

Hepatitis viruses are primary causative agents of hepatitis and represent a major source of public health problems in the world. The host innate immune system forms the first line of defense against hepatitis viruses. Hepatitis viruses are sensed by specific pathogen recognition receptors (PRRs) that subsequently trigger the innate immune response and interferon (IFN) production. However, hepatitis viruses evade host immune surveillance via multiple strategies, which help compromise the innate immune response and create a favorable environment for viral replication. Therefore, this article reviews published findings regarding host innate immune sensing and response against hepatitis viruses. Furthermore, we also focus on how hepatitis viruses abrogate the antiviral effects of the host innate immune system.

Keywords: antiviral innate immunity; hepatitis virus; immune evasion; replication; viral infection.

Publication types

Review