Molecular docking analysis of C-phycocyanin with VEGFR2

Saira M Bannu; Dakshayani Lomada; Sravani Varala; Madhava C Reddy

doi:10.6026/97320630016869

Molecular docking analysis of C-phycocyanin with VEGFR2

Bioinformation. 2020 Nov 30;16(11):869-877. doi: 10.6026/97320630016869. eCollection 2020.

Authors

Saira M Bannu¹, Dakshayani Lomada², Sravani Varala¹, Madhava C Reddy¹

Affiliations

¹ Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa AP 516005, India.
² Department of Genetics and Genomics, Yogi Vemana University, Kadapa, AP 516005, India.

Abstract

C-phycocyanin (C-PC) produced from cyanobacterial species finds application in drug development. Therefore, it is of interest to document the molecular binding features of C-PC with the vascular endothelial growth factor receptor 2 (VEGFR2). C-PC showed H-bond interactions with residues on both sides of the Deusche Forschugsgemein-Schalt (DFG) loop (Asp1046-Phe1047-Gly1048). A hydrophobic association between the activation loop and the DFG residue (Gly1048) helps to inhibit the activity of VEGFR2 kinases. Thus, C-PC is reported as a potential angiogenesis inhibitor for VEGFR2 in combating cancer.

Keywords: Angiogenesis; C-Phycocyanin; Cancer treatment; Molecular docking; VEGFR2.