Combining flow and reserve measurement during myocardial perfusion imaging: A new era for myocardial perfusion scintigraphy?

Arch Cardiovasc Dis. 2021 Dec;114(12):818-827. doi: 10.1016/j.acvd.2021.10.006. Epub 2021 Nov 17.

Abstract

Myocardial flow reserve represents the ratio of myocardial blood flow between stress and rest, giving functional information about both macrocirculation and microcirculation; it has been reported extensively in positron emission tomography, with an increase in diagnostic performance, providing important prognostic information and being a powerful tool to guide therapy. Advances in single photon emission computed tomography, with the widespread availability of "cadmium zinc telluride" single photon emission computed tomography cameras, raise the question of myocardial flow reserve use in daily clinical practice. In this article, we review the pathophysiology of myocardial blood flow and myocardial flow reserve, and the initial data available from single photon emission computed tomography myocardial blood flow and myocardial flow reserve evaluation; we also discuss potential limitations to the wider implementation of flow evaluation in single photon emission computed tomography.

Keywords: Blood flow; Coronary artery disease; Flux myocardique; Maladie coronarienne; Myocardial flow reserve; Réserve coronaire; SPECT; TEMP.

Publication types

  • Review

MeSH terms

  • Coronary Angiography
  • Coronary Artery Disease*
  • Humans
  • Myocardial Perfusion Imaging*
  • Perfusion
  • Tomography, Emission-Computed, Single-Photon