The Epidemiology of Central Nervous System Tumors

Stephen S Francis; Quinn T Ostrom; David J Cote; Timothy R Smith; Elizabeth Claus; Jill S Barnholtz-Sloan

doi:10.1016/j.hoc.2021.08.012

The Epidemiology of Central Nervous System Tumors

Hematol Oncol Clin North Am. 2022 Feb;36(1):23-42. doi: 10.1016/j.hoc.2021.08.012.

Authors

Stephen S Francis¹, Quinn T Ostrom², David J Cote³, Timothy R Smith⁴, Elizabeth Claus⁵, Jill S Barnholtz-Sloan⁶

Affiliations

¹ Department of Neurological Surgery, Division of Neuro and Molecular Epidemiology, University of California San Francisco School of Medicine, 1450 3rd Street, HD442, San Francisco, CA 94158, USA. Electronic address: Stephen.francis@ucsf.edu.
² Department of Neurosurgery, Duke University School of Medicine, 571 Research Drive, MSRB-1, Rm 442, Durham, NC 27710, USA.
³ Department of Neurosurgery, Keck School of Medicine, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA 90033, USA.
⁴ Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Avenue, Boston, MA 02115, USA.
⁵ Department of Neurosurgery, Yale University, Yale School of Public Health, Brigham and Women's Hospital, 60 College Street, New Haven, CT 06510, USA.
⁶ Center for Biomedical Informatics and Information Technology, Trans-Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), NCI Shady Grove, 9609 Medical Center Dr, Rockville, MD 20850, USA.

PMID: 34801162
DOI: 10.1016/j.hoc.2021.08.012

Abstract

This article reviews the current epidemiology of central nervous system tumors. Population-level basic epidemiology, nationally and internationally, and current understanding of germline genetic risk are discussed, with a focus on known and well-studied risk factors related to the etiology of central nervous system tumors.

Keywords: Brain tumors; Central nervous system tumors; Epidemiology; Etiology; Glioblastoma; Glioma; Meningioma.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Brain Neoplasms*
Central Nervous System Neoplasms* / epidemiology
Central Nervous System Neoplasms* / genetics
Glioma*
Humans
Meningeal Neoplasms*
Meningioma*