A comparison of the antimicrobial resistance of fecal Bacteroides isolates and assessment of the composition of the intestinal microbiotas of carbapenem-treated and non-treated persons from Belgium and Hungary

Anaerobe. 2022 Feb:73:102480. doi: 10.1016/j.anaerobe.2021.102480. Epub 2021 Nov 18.

Abstract

The antimicrobial susceptibilities of Bacteroides strains isolated from the feces of imipenem-treated patients from Belgium and Hungary were compared with those isolated from the normal microbiota from these two and five other European countries and assessed. Of the 10 antibiotics tested, highly significant differences were found with cefoxitin (decrease for Belgium and for this two and the five countries from the previous study), clindamycin (decrease for Belgium and for this two and the five countries from the previous study) and moxifloxacin (increase for Belgium and for this two and the five countries from the previous study) relative to normal microbiota strains reported earlier. Imipenem treatment brought about modest, but notable differences in the compositions of the microbiomes where there was less diversity in the treated group relative to the non-treated group.

Keywords: Antibiotic resistance; B. fragilis; Bacteroides; Carbapenems; Microbiome.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteroides
  • Bacteroides Infections* / drug therapy
  • Bacteroides Infections* / epidemiology
  • Bacteroides fragilis
  • Belgium / epidemiology
  • Carbapenems / pharmacology
  • Carbapenems / therapeutic use
  • Drug Resistance, Bacterial
  • Feces
  • Gastrointestinal Microbiome*
  • Humans
  • Hungary / epidemiology
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Carbapenems