Pancreatic Cancer Surveillance and Novel Strategies for Screening

Beth Dudley; Randall E Brand

doi:10.1016/j.giec.2021.08.008

Pancreatic Cancer Surveillance and Novel Strategies for Screening

Gastrointest Endosc Clin N Am. 2022 Jan;32(1):13-25. doi: 10.1016/j.giec.2021.08.008.

Authors

Beth Dudley¹, Randall E Brand²

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, 5200 Centre Avenue, Suite 409, Pittsburgh, PA 15232, USA.
² Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, 5200 Centre Avenue, Suite 409, Pittsburgh, PA 15232, USA. Electronic address: brandre@upmc.edu.

PMID: 34798981
DOI: 10.1016/j.giec.2021.08.008

Abstract

Individuals with a genetic susceptibility to pancreatic ductal adenocarcinoma (PDAC) may benefit from surveillance to increase the likelihood of early detection. Currently, candidates for surveillance are identified based on genetic test results and family history of PDAC, and surveillance is accomplished through imaging of the pancreas (endoscopic ultrasound or MRI). Novel methods that incorporate personalized risk, biomarkers, and radiomics are being investigated in an attempt to improve identification of at-risk individuals and to increase detection of precursor and early-stage lesions.

Keywords: Familial pancreatic cancer; Hereditary pancreatic cancer; Pancreatic cancer screening; Pancreatic cancer surveillance.

Publication types

Review

MeSH terms

Carcinoma, Pancreatic Ductal* / diagnostic imaging
Carcinoma, Pancreatic Ductal* / epidemiology
Early Detection of Cancer
Humans
Magnetic Resonance Imaging
Pancreatic Neoplasms* / diagnostic imaging
Pancreatic Neoplasms* / epidemiology
Risk Factors