Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma

E V Inzhevatkin; A V Baron; M B Volkova; N G Maksimov; N K Golubenko; M V Loshkareva; A P Puzyr'; N O Ronzhin; V S Bondar

doi:10.1007/s10517-021-05335-9

Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma

Bull Exp Biol Med. 2021 Nov;172(1):77-80. doi: 10.1007/s10517-021-05335-9. Epub 2021 Nov 19.

Authors

E V Inzhevatkin^{1

2}, A V Baron³, M B Volkova⁴, N G Maksimov⁵, N K Golubenko⁶, M V Loshkareva⁷, A P Puzyr'^{7

3}, N O Ronzhin³, V S Bondar³

Affiliations

¹ International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia. inscience@mail.ru.
² Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia. inscience@mail.ru.
³ Institute of Biophysics, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
⁴ Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia.
⁵ Institute of Chemistry and Chemical Technology, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
⁶ Krasnoyarsk Regional Clinical Center of Maternity and Child Protection, Krasnoyarsk, Russia.
⁷ International Scientific Center of Extremal Organism State Research, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.

PMID: 34797450
DOI: 10.1007/s10517-021-05335-9

Abstract

Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

Keywords: EPR-spectrometry; biochemical changes in blood plasma; biodistribution; detonation synthesis nanodiamonds; intravenous administration.

MeSH terms

Administration, Intravenous
Alanine Transaminase / metabolism
Animals
Aspartate Aminotransferases / metabolism
Bilirubin / analysis
Liver / metabolism*
Lung / metabolism*
Male
Mice
Mice, Inbred ICR
Nanodiamonds / analysis*
Nanotechnology
Plasma / chemistry*
Tissue Distribution

Substances

Nanodiamonds
Aspartate Aminotransferases
Alanine Transaminase
Bilirubin