Nanomedicine and Periodontal Regenerative Treatment

Dent Clin North Am. 2022 Jan;66(1):131-155. doi: 10.1016/j.cden.2021.06.005. Epub 2021 Aug 10.

Abstract

Current periodontal treatments aim to control bacterial infection and decrease inflammation. To optimize contemporary conventional treatments that present limitations owing to an inability to reach the lesion site, new methods are based on nanomedicine. Nanomedecine allows delivery of host-modulatory drugs or antibacterial molecules at the lesion site in an optimal concentration with decreased toxicity and risk of systemic side effects. Chitosan and polylactic-co-glycolic acid-loaded nanoparticles, carbon quantum dots, and mesoporous silicates open new perspectives in periodontitis management. The potential therapeutic impact of the main nanocarriers is discussed.

Keywords: Biomaterials; Inflammation; Nanocarriers; Nanomedicine; Periodontitis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Chitosan*
  • Humans
  • Nanomedicine
  • Nanoparticles*
  • Periodontitis* / therapy

Substances

  • Anti-Bacterial Agents
  • Chitosan