Phycocyanin, a super functional ingredient from algae; properties, purification characterization, and applications

Int J Biol Macromol. 2021 Dec 15;193(Pt B):2320-2331. doi: 10.1016/j.ijbiomac.2021.11.064. Epub 2021 Nov 16.

Abstract

Phycocyanins (PCYs) are a group of luxuriant bioactive compounds found in blue-green algae with an estimated global market of about US$250 million within this decade. The multifarious markets of PCYs noted by form (e.g. powder or aqueous forms), by grade (e.g. analytical, cosmetic, or food grades), and by application (such as biomedical, diagnostics, beverages, foods, nutraceuticals and pharmaceuticals), show that the importance of PCYs cannot be undermined. In this comprehensive study, an overview on PCY, its structure, and health-promoting features are diligently discussed. Methods of purification including chromatography, ammonium sulfate precipitation and membrane filtration, as well as characterization and measurement of PCYs are described. PCYs could have many applications in food colorants, fluorescent markers, nanotechnology, nutraceutical and pharmaceutical industries. It is concluded that PCYs offer significant potentials, although more investigations regarding its purity and safety are encouraged.

Keywords: Applications; Health benefits; Phycocyanins; Purification; Structural classification.

Publication types

  • Review

MeSH terms

  • Ammonium Sulfate / chemistry
  • Animals
  • Coloring Agents / chemistry
  • Cyanobacteria / chemistry*
  • Dietary Supplements
  • Drug Industry / methods
  • Food Coloring Agents / chemistry
  • Humans
  • Phycocyanin / chemistry*

Substances

  • Coloring Agents
  • Food Coloring Agents
  • Phycocyanin
  • Ammonium Sulfate