Dynorphin, won't you myelinate my neighbor?

Xiaoyun Ding; Matthew N Rasband

doi:10.1016/j.neuron.2021.10.027

Dynorphin, won't you myelinate my neighbor?

Neuron. 2021 Nov 17;109(22):3537-3539. doi: 10.1016/j.neuron.2021.10.027.

Authors

Xiaoyun Ding¹, Matthew N Rasband²

Affiliations

¹ Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
² Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: rasband@bcm.edu.

PMID: 34793703
DOI: 10.1016/j.neuron.2021.10.027

Abstract

Accumulating evidence supports the prevalence of experience-dependent oligodendrocyte precursor cell (OPC) differentiation and myelination in learning and memory. However, the mechanisms remain unknown. In this issue of Neuron, Osso et al., (2021) report that stress causes the secretion of dynorphin by unmyelinated axons, which induces OPC differentiation and myelination of neighboring axons.

Publication types

Comment

MeSH terms

Axons
Cell Differentiation
Dynorphins*
Oligodendrocyte Precursor Cells*
Oligodendroglia

Substances

Dynorphins

Grants and funding

R35 NS122073/NS/NINDS NIH HHS/United States