A Patient with Primary Open-Angle Glaucoma with Re-Elevated Nocturnal Sitting Intraocular Pressure after Restarting Medical Therapy due to a Bleb Failure

J Nippon Med Sch. 2021;88(5):509-511. doi: 10.1272/jnms.JNMS.2021_88-521.

Abstract

We describe the case of a primary open-angle glaucoma patient with re-elevated nocturnal sitting intraocular pressure (IOP) after restarting medical therapy due to a failing bleb. IOP was markedly higher than diurnal IOP during multiple-drug therapy in both eyes, but it did not increase in the left eye with a functional bleb without medical therapy after trabeculectomy with adjuvant mitomycin. However, nocturnal sitting IOP was re-elevated after restarting multiple-drug therapy due to a failing bleb, while diurnal IOP was maintained at a low level.

Keywords: 24-hour intraocular pressure; diurnal intraocular pressure variation; glaucoma; nocturnal intraocular pressure; trabeculectomy.

Publication types

  • Case Reports

MeSH terms

  • Circadian Rhythm* / physiology
  • Female
  • Glaucoma, Open-Angle* / diagnosis
  • Glaucoma, Open-Angle* / drug therapy
  • Glaucoma, Open-Angle* / physiopathology
  • Humans
  • Intraocular Pressure* / physiology
  • Middle Aged
  • Postoperative Period
  • Sitting Position
  • Tonometry, Ocular
  • Trabeculectomy* / adverse effects