Mechanical unloading aggravates bone destruction and tumor expansion in myeloma

Kotaro Tanimoto; Masahiro Hiasa; Hirofumi Tenshin; Jumpei Teramachi; Asuka Oda; Takeshi Harada; Yoshiki Higa; Kimiko Sogabe; Masahiro Oura; Ryohei Sumitani; Tomoyo Hara; Itsuro Endo; Toshio Matsumoto; Eiji Tanaka; Masahiro Abe

doi:10.3324/haematol.2021.278295

Mechanical unloading aggravates bone destruction and tumor expansion in myeloma

Haematologica. 2022 Mar 1;107(3):744-749. doi: 10.3324/haematol.2021.278295.

Authors

Affiliations

¹ Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima.
² Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima. mhiasa@tokushima-u.ac.jp.
³ Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama.
⁴ Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima.
⁵ Department of Bioregulatory Sciences, Tokushima University Graduate School of Medical Sciences, Tokushima.
⁶ Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima.
⁷ Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima. masabe@tokushima-u.ac.jp.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Resorption*
Humans
Multiple Myeloma* / pathology
Osteoclasts
Osteolysis*

Grants and funding

Funding: this work was supported in part by the JSPS KAKENHI grant numbers JP16K11504, JP17H05104, JP17KK0169, JP18K16118, JP18K08329, JP18H06294, JP19K21382 and 19K22719; and the Research Clusters program of Tokushima University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.