A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Abstract

A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2-5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC₅₀ values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC₅₀, 214.5 µM).

Keywords: Curcuma zedoaria; α-glucosidase inhibitor; rhizomes.